dokument toxcon2005

TOP TEN v interakcích léčiv
(Zpracovala společnost Favea Kopřivnice)
V tabulce jsou černě vyznačena léčiva, která interagují přes CYP (cytochrom P450):
TOP TEN v interakcích léčiv
strana 1/6
WARFARIN
warfarinum
natricum
(warfarin sodná
sůl)
NSAIDs*
Lawarin 2, Lawarin 5,
Warfarin 3-SL, Warfarin
diclofenacum natricum
5-SL, Warfarin Orion 3 mg, (diklofenak sodná sůl)
Warfarin Orion 5 mg
diclofenacum kalicum
(diklofenak draselná sůl)
diclofenacum epolaminum
(diklofenak-epolamin)
diclofenacum diethylaminum (diethylaminová sůl
diklofenaku)
diclofenacum (diklofenak)
diclofenacum (diklofenak)
/ mistoprostrol
diflunisalum (diflunisal)
etodolacum (etodolak)
flurbiprofenum (flurbiprofen)
ibuprofenum (ibuprofen)
ibuprofenum lysinicum
(ibuprofen-lysin)
indometacinum
(indometacin)
ketoprofenum
(ketoprofen)
dexketoprofenum trometamoli (dexketoprofen trometamol)
ketorolacum (ketorolak)
acidum mefenamicum
(kyselina mefenamová)
meloxicamum (meloxikam)
nabumetonum
(nabumeton)
naproxenum natricum
(sodná sůl naproxenu)
naproxenum (naproxen)
oxaprozinum (oxaprozin)
piroxicamum
(piroxikam)
piroxicamum betadexum
(piroxikam-betadex)
sulindacum (sulindak)
tolmetinum (tolmetin)
WARFARIN
warfarinum
natricum
(warfarin sodná
sůl)
Almiral (inj.), Almiral 50, Almiral Gel, APO-Diclo 25 mg, APO-Diclo 50 mg,
APO-Diclo SR 100, Diclofen 25 SVUS
Voltaren Actigo, Voltaren Actigo Extra, Voltaren Rapid 50 mg
Flector EP Gel, Flector EP Rapid 50 mg, Flector EP Tissugel
Almiral Gel, Voltaren Emulgel
Dicloreum 100, Inflamac 75 SR, Myogit 25, Myogit 50
Strepfen, Transactlat
Advil Cold, Advil Ultra, APO-Ibuprofen 400 mg, Brufen 400
Ibalgin Fast, Nurofen Advance
APO-Indomethacin, APO-Indomethacin 25, APO-Indomethacin 50, Elmetacin, Indobene, Indocollyre 0,1% (oph.sol.), Indometacin 50 (Berlin-Chemie),
Indometacin 100 (Berlin-Chemie), Indometacin (RatioPharm Gel), Vonum
Cutan
Fastum Gel, Ketobene, Ketobene 50, Ketobene 100, Ketofen 1% A.U.V.,
Ketofen 10% A.U.V., Ketofen 10 mg A.U.V., Ketofen 20 mg A.U.V., Ketofen 5
mg A.U.V., Ketonal, Ketonal 5% krém, Ketonal Forte, Ketonal Retard, Ketona
UNO 200 mg, Profenid 50 mg, Profenid 100 mg
Dexoket
Celomix 15 mg
Relifex
Aleve, Nalgesin Forte, Nalgesin S
Emoxen 10%, Napsyn
Dayrun
APO-Piroxicam 10, APO-Piroxicam 20, Flamexin, Flamexin Eff., Hotemin
(inj., crm.), Hotemin 10 mg, Hotemin 20 mg, Piroxicam AL 10, Piroxicam AL
20, Pro-Roxikam 10 mg, Pro-Roxikam 20 mg, Reumador
Flamexin, Flamexin Eff.
SULFA LÉČIVA
erythromycinum
Lawarin 2, Lawarin 5,
(erythromycin)
Warfarin 3-SL, Warfarin
5-SL, Warfarin Orion 3 mg,
sulfafurazolum
Warfarin Orion 5 mg
(sulfisoxazol)
sulfamethizolum
(sulfamethizol)
sulfamethoxazolum
(sulfamethoxazol)
sulfafurazolum (sulfisoxazol)
trimethoprimum/
sulfamethoxazolum
(trimethoprim/
sulfamethoxazol)
TOP TEN v interakcích léčiv
Biseptol 120, Biseptol 480, Bismoral 480, Cotrimoxazol AL, Cotrimoxazol AL
Forte, Primotren (inj.), Sumetrolim
Triprim 100 mg, Triprim 200 mg/Biseptol 120, Biseptol 480, Bismoral 480,
Cotrimoxazol AL, Cotrimoxazol AL Forte, Primotren (inj.), Sumetrolim
strana 2/6
WARFARIN
warfarinum
natricum
(warfarin sodná
sůl)
MAKROLIDY
Lawarin 2, Lawarin 5,
Warfarin 3-SL, Warfarin
5-SL, Warfarin Orion 3 mg,
Warfarin Orion 5 mg
azithromycinum (azithromycin)
clarithromycinum (klarithromycin)
dirithromycinum (dirithromycin)
erythromycinum base
erythromycini ethylsuccinas
(erythromycin ethylsukcinát)
erythromycini stearas (erythromycin stearát)
erythromycini estolas (erythromycin estolát)
erythromycinum (erythromycin) / sulfafurazolum
(sulfisoxazol)
troleandomycinum (troleandomycin)
WARFARIN
Azitrox 100 SUS, Azitrox 250, Azitrox 500, Sumamed (cps.), Sumamed
125 mg, Sumamed 500 mg, Sumamed 500 mg (inf.), Sumamed 600 mg,
Sumamed Forte sirup, Sumamed sirup, Sumamed STD, Zitrocin 125 mg,
Zitrocin 250 mg (cps.), Zitrocin 500 mg, Zitrocin 500 mg (inf.), Zitrocin
Forte sirup, Zitrocin sirup, Zitrocin STD
Clarexid 250 mg, Clarexid 500 mg, Clarithromycin Grun. 125 mg, Clarithromycin Grun. 187,5 mg, Clarithromycin Grun. 250 mg
Erythromycin (RatioPharm TS), Meromycin
CHINOLONY**
Lawarin 2, Lawarin 5,
warfarinum
Warfarin 3-SL, Warfarin
natricum
alatrofloxacin
5-SL, Warfarin Orion 3 mg,
(warfarin sodná sůl)
Warfarin Orion 5 mg
ciprofloxacini hydrochloridum
monohydricum (monohydrát
ciprofloxacin hydrochloridu)
ciprofloxacini lactas
(ciprofloxacin laktát)
enoxacinum (enoxacin)
gatifloxacinum (gatifloxacin)
levofloxacinum
(levofloxacin)
lomefloxacinum hydrochloridum monohydricum
(monohydrát lomefloxacin
hydrochloridu)
moxifloxacini hydrochloridum
(moxifloxacin hydrochlorid)
norfloxacinum (norfloxacin)
norfloxacinum (norfloxacin)
ofloxacini hydrochloridum
(ofloxacin hydrochlorid)
Cifloxinal, Cifran 250 mg, Cifran 500 mg, Cifran 750 mg, Ciloxan, Ciprum
250 mg
Ciplox (inf.), Ciplox infúzní roztok, Ciprinol 100 mg/10 ml (inf.)
Levofloxacin „ZAK“ 250 mg, Levofloxacin „ZAK“ 5 mg/ml (inf.), Levofloxacin „ZAK“ 500 mg, Oftaquix 5 mg/ml (oph.sol.), Tavanic 250 mg
Okacin (oph.sol.)
Avelox
Gyrablock 400, Nolicin, Norfloxacin (RatioPharm 400 mg)
Floxal, Ofloxin 100, Ofloxin 200, Ofloxin 400, Ofloxin (inf.), Tarivid I.V.
200, Tarivid I.V. 400 AVE D, Taroflox 200, Taroflox 400, Zanocin 100 mg,
Zanocin 200 mg
sparfloxacinum (sparfloxacin)
trovafloxacinum (trovafloxacin)
WARFARIN
FENYTOIN
Lawarin 2, Lawarin 5,
warfarinum
Warfarin 3-SL, Warfarin
natricum
5-SL, Warfarin Orion 3 mg,
(warfarin sodná sůl)
Warfarin Orion 5 mg
phenytoinum
(fenytoin)
Epilan D Gerot, Sanepil, Sodanton
phenytoinum natricum
(sodná sůl fenytoinu)
Epanutin Parenteral (inj.)
TOP TEN v interakcích léčiv
strana 3/6
ACE INHIBITORY
SUPLEMENTY DRASLÍKU
benazeprili hydrochloridum (benaze- Fortekor 5 A.U.V., Fortekor 20 A.U.V.
pril hydrochlorid)
APO-Capto 12,5 mg, APO-Capto 25
captoprilum (kap- mg, APO-Capto 50 mg, APO-Capto
topril)
100 mg, Capoten 12,5 mg, Capoten
25 mg, Capoten 50 mg, Captopril 25
SVUS
enalaprilum (ena- Enapirex 5 mg, Enapirex 10 mg,
lapril)
Enapirex 20 mg
enalaprili maleas
(enalapril maleat)
fosinoprilum
(fosinopril)
Fosinopril-TEVA 10 mg, Fosinopril-TEVA 20 mg
Dapril 5, Dapril 10, Dapril 20, Diroton
2,5 mg, Diroton 5 mg, Diroton 10 mg,
Diroton 20 mg, Irumed 5 mg, Irumed
10 mg, Irumed 20 mg, Lisigamma 10,
Lisigamma 20
moexiprilum
(moexipril)
Moex 7,5, Moex 15
perindoprilum
(perindopril)
Coverex, Perindopril 2 mg Servier,
Perindopril 4 mg Servier, Perindopril
8 mg Servier, Perindopril Arginine
2,5 mg Serv., Perindopril Arginine 10
mg Serv.
ramiprilum
(ramipril)
trandolaprilum
(trandolapril)
Aminoplasmal 5% (inf.), Aminoplasmal 10% E (inf.),
Aminoplasmal 15% (inf.), Nutriflex Lipid Peri (inf.),
Nutriflex Lipid Plus (inf.)
kalii dihydrogenophosphas
(dihydrogenfosforečnan draselný)
Aqua Viva A.U.V., Lactade Plus A.U.V., Mopasol (inj.),
Nutriflex Basal (inf.), Nutriflex Peri (inf.), Nutriflex
Special (inf.), Peptisorb, Riedidlo A A.U.V. (inj.), Živá
voda A.U.V., Zřeďovač A A.U.V. (inj.)
kalii hydrogenocarbonas
(monodraselná sůl kyseliny uhličité)
APO-Enalapril 5 mg, APO-Enalapril
10 mg, APO-Enalapril 20 mg, Berlipril
kalii citras monohydricus (citronan drasel5, Berlipril 10, Berlipril 20, Ednyt 2,5
ný monohydrát)
mg, Ednyt 5 mg, Ednyt 10 mg, Ednyt
20 mg
lisinoprilum
dihydricum
(lisinopril dihydrát)
perindoprilum
erbuminum
(perindopril
erbumin)
quinaprili hydrochloridum
(quinapril hydrochlorid)
kalii acetas
(octan draselný)
kalii chloridum
(chlorid draselný)
Blemaren N
Analog P-AM, Fresubin HP Energy, Lectade Plus
A.U.V., Nenatal, Nutridrink multi Fibre S přích.jah., Nutridrink multi Fibre S přích.pom., Nutridrink multi Fibre
S přích.van., Nutrilon 1 Low Lactose, Nutrilon 1 soya,
Nutrini, Nutrison Energy, Nutrison Standard, Peptisorb,
Supportan Neutral, Survimed OPD Neutral
Aminomix 1 (inf.), Aminomix 2 (inf.), Aqua Viva A.U.V.,
Ardeaelytosol D 1/1 (inf.), Ardeaelytosol D 1/2 (inf.),
Ardeaelytosol D 1/3 (inf.), Ardeaelytosol D 1/5 (inf.),
Ardeaelytosol D 2/3 (inf.)
Coverex, Noliprel, Noliprel Forte,
Perindopril 2 mg Servier, Perindopril
2 mg Tauret, Perindopril 4 mg Servier
Accupro 5, Accupro 10, Accupro 20,
Accuzide, Accuzide 20, Quilo AL
10/12,5 mg
Amprilan 1,25, Amprilan 2,5, Amprilan 5, Amprilan 10, Hartil 1,25 mg,
Hartil 2,5 mg, Hartil 5 mg, Hartil 10
mg, Miril 1,25 mg
Gopten 0,5 mg, Gopten 2 mg, Gopten 4 mg, Tarka
TOP TEN v interakcích léčiv
strana 4/6
ACE INHIBITORY
SPIRONOLAKTON
benazeprili hydrochloridum (benazepril hydrochlorid)
Fortekor 5 A.U.V., Fortekor 20 A.U.V.
captoprilum
(kaptopril)
APO-Capto 12,5 mg, APO-Capto 25 mg, APO-Capto 50 mg,
APO-Capto 100 mg, Capoten 12,5 mg, Capoten 25 mg, Capoten
50 mg, Captopril 25 SVUS
enalaprilum (enalapril)
Enapirex 5 mg, Enapirex 10 mg, Enapirex 20 mg
enalaprili maleas
(enalapril maleat)
APO-Enalapril 5 mg, APO-Enalapril 10 mg, APO-Enalapril 20
mg, Berlipril 5, Berlipril 10, Berlipril 20, Ednyt 2,5 mg, Ednyt 5
mg, Ednyt 10 mg, Ednyt 20 mg
fosinoprilum (fosinopril)
lisinoprilum
dihydricum
(lisinopril dihydrát)
moexiprilum (moexipril)
perindoprilum
(perindopril)
perindoprilum erbuminum (perindopril
erbumin)
quinaprili hydrochloridum (quinapril
hydrochlorid)
ramiprilum
(ramipril)
trandolaprilum
(trandolapril)
Fosinopril-TEVA 10 mg, Fosinopril-TEVA 20 mg
Dapril 5, Dapril 10, Dapril 20, Diroton 2,5 mg, Diroton 5 mg, Diroton 10 mg, Diroton 20 mg, Irumed 5 mg, Irumed 10 mg, Irumed
20 mg, Lisigamma 10, Lisigamma 20
Moex 7,5, Moex 15
Coverex, Perindopril 2 mg Servier, Perindopril 4 mg Servier,
Perindopril 8 mg Servier, Perindopril Arginine 2,5 mg Serv.,
Perindopril Arginine 10 mg Serv.
Coverex, Noliprel, Noliprel Forte, Perindopril 2 mg Servier,
Perindopril 2 mg Tauret, Perindopril 4 mg Servier
Accupro 5, Accupro 10, Accupro 20, Accuzide, Accuzide 20,
Quilo AL 10/12,5 mg
Amprilan 1,25, Amprilan 2,5, Amprilan 5, Amprilan 10, Hartil 1,25
mg, Hartil 2,5 mg, Hartil 5 mg, Hartil 10 mg, Miril 1,25 mg
Gopten 0,5 mg, Gopten 2 mg, Gopten 4 mg, Tarka
DIGOXIN
digoxinum
(digoxin)
antitoxinum digitalis
ovillum FAB (ovčí
digitalisový antitoxin
FAB)
AMIODARON
Digoxin 0,125 Léčiva, Digoxin 0,25 Léčiva, Digoxin Spofa,
Digoxin Galena
antitoxinum digitalis
ovillum FAB (ovčí
digitalisový antitoxin
FAB)
amiodaroni hydrochloridum
(amiodaron hydrochlorid)
Amiodaron 100 mg Generics,
Amiodaron 200 mg Generics
Digitalis-Antidot Roche (inj.)
DIGOXIN
digoxinum
(digoxin)
Verospiron, Verospiron 50 mg,
spironolactonum (spironolakton) Verospiron 100 mg
VERAPAMIL
Digoxin 0,125 Léčiva, Digoxin 0,25 Léčiva, Digoxin Spofa,
Digoxin Galena
Isoptin 40 mg, Isoptin 80 mg, Isoptin SR
verapamili
240 mg, Lekoptin (inj.), Lekoptin 40 mg,
hydrochloridum
Lekoptin 80 mg, Lekoptin 120 mg, Lekoptin
(verapamil hydrochlorid) Retard, Tarka, Verahexal 40, Verahexal 80,
Verahexal 120
Digitalis-Antidot Roche (inj.)
TOP TEN v interakcích léčiv
strana 5/6
THEOFYLIN
aminophyllinum
hydricum (aminofylin
hydrát)
aminophyllinum (aminofylin)
CHINOLONY**
Syntophyllin
Aminophyllinum LEK,
Aminophyllinum Retard
LEK
oxtriphyllin
alatrofloxacin
ciprofloxacini
hydrochloridum monohydricum
Cifloxinal, Cifran 250 mg, Cifran 500 mg, Cifran 750 mg, Ciloxan,
(monohydrát ciprofloxacin hydrochlo- Ciprum 250 mg
ridu)
ciprofloxacini lactas
Ciplox (inf.), Ciplox infúzní roztok, Ciprinol 100 mg/10 ml (inf.)
(ciprofloxacin laktát)
theophyllinum
(theofylin)
Afonilum SR 125 mg,
Afonilum SR 250 mg,
Afonilum SR 375 mg,
Afonilum SR 500 mg,
Euphyllin CR N 100,
Euphyllin CR N 200,
Euphyllin CR N 300,
Euphyllin CR N 400,
Spophyllin Retard 100
mg, Spophyllin Retard
250 mg, Teotard 200,
Teotard 350, Theoplus
100, Theoplus 300
theophyllinum
monohydricum
(monohydrát theofylinu)
Oxantil (inj.), Syntophyllin
gatifloxacinum
(inj.), Theoplus 100,
(gatifloxacin)
Theoplus 300
enoxacinum
(enoxacin)
levofloxacinum
(levofloxacin)
Levofloxacin „ZAK“ 250 mg, Levofloxacin „ZAK“ 5 mg/ml (inf.),
Levofloxacin „ZAK“ 500 mg, Oftaquix 5 mg/ml (oph.sol.), Tavanic
250 mg
lomefloxacinum hydrochloridum monohydricum
Okacin (oph.sol.)
(monohydrát lomefloxacin hydrochloridu)
moxifloxacini hydrochloridum (moxif- Avelox
loxacin hydrochlorid)
norfloxacinum (norfloxacin)
Gyrablock 400, Nolicin, Norfloxacin (RatioPharm 400 mg)
ofloxacini hydrochloridum
(ofloxacin hydrochlorid)
Floxal, Ofloxin 100, Ofloxin 200, Ofloxin 400, Ofloxin (inf.), Tarivid
I.V. 200, Tarivid I.V. 400 AVE D, Taroflox 200, Taroflox 400, Zanocin 100 mg, Zanocin 200 mg
sparfloxacinum (sparfloxacin)
trovafloxacinum (trovafloxacin)
* nezahrnuje COX-2 inhibitory
** včetně ciprofloxacinu, enoxacinu, norfloxacinu, ofloxacinu
erythromycinum A
erythromycinum A cyclic
11,12-carbonatum
erythromycinum
9-(O-((2-methoxyethoxy)
methylum)O
Aknefug-EL, Aknemycin (liq.), Aknemycin 2000, Aknemycin
Plus, Eryfluid, Erythrocin I.V., Erythromycin (RathioPharm
TS), Isotrexin, Meromycin, Zineryt
Davercin
Rolicyn, Roxithromycin AL 150
TOP TEN v interakcích léčiv
strana 6/6